Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity.
نویسندگان
چکیده
N-Acetyl-S-farnesyl cysteine (AFC) is the minimal synthetic substrate for the enzyme Icmt, which methylates prenylated proteins. The desthio-AFC isostere 2 has been synthesized in racemic form. This analog was not an Icmt substrate, but instead a weak inhibitor with an IC50 of approximately 325 microM.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 15 22 شماره
صفحات -
تاریخ انتشار 2005